Copper(II)-catalyzed ortho-functionalization of 2-arylpyridines with acyl chlorides.
نویسندگان
چکیده
Copper-catalyzed ortho-benzoxylation of 2-arylpyridine sp(2) C-H bonds with acyl chloride is described. Notably, switching the base from t-BuOK to Li(2)CO(3) causes chlorination of the C-H bond to take place.
منابع مشابه
Palladium(II)-catalyzed othro-C-H-benzoxylation of 2-arylpyridines by oxidative coupling with aryl acylperoxides.
A palladium(II)-catalyzed ortho-benzoxylation of 2-arylpyridines with aryl acylperoxides was developed. With pyridyl as directing group, the benzoxylation reaction exhibits remarkable regioselectivity and excellent functional group tolerance, providing the products in up to 87% yield.
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ورودعنوان ژورنال:
- Chemical communications
دوره 47 13 شماره
صفحات -
تاریخ انتشار 2011